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Drug intelligence / Profile preview
MSC secretory peptide cocktail
- Development stage
- Preclinical
- Lead developer
- King's College London
- Modality
- Recombinant Proteins and Enzymes, Peptides
01
Overview
MSC secretory peptide cocktail is a combination of mesenchymal stromal cell (MSC)-derived secretory molecules, specifically consisting of human recombinant annexin A1 (ANXA1), stromal cell-derived factor-1 (SDF-1/CXCL12), and complement component C3 (C3a). Developed by researchers at King's College London, this cocktail is designed to improve the functional survival and quality of human islets and stem cell-derived islets (SC-islets) for transplantation therapy in type 1 diabetes. Pretreatment with the cocktail protects islets against cytokine-induced apoptosis, increases ATP-coupled respiration, and enhances glucose-stimulated insulin secretion (GSIS).
- Other names
- annexin A1 + stromal cell-derived factor-1 + complement component C3MSC-secreted GPCR ligands cocktailMSC-secreted peptides cocktail
02
Targets
CXCR7 (CXC chemokine receptor 7)C3AR1 (Complement C3a receptor)CXCR4 (C-X-C motif chemokine receptor 4)FPR2 (Formyl peptide receptor type 2)
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