MSI1-C-terminus decoy peptide

MSI1-C-terminus decoy peptide is a therapeutic peptide designed to disrupt the interaction between the RNA-binding protein Musashi1 (MSI1) and Argonaute2 (AGO2). In glioblastoma multiforme (GBM), MSI1 translocates to the cytoplasm under stress conditions and recruits AGO2 to form a complex that modulates mRNA stability, promoting tumor cell proliferation and survival. This decoy peptide mimics the C-terminal domain of MSI1, which is the site of direct binding to AGO2, thereby competitively inhibiting the formation of the MSI1/AGO2 complex. Preclinical studies in orthotopic mouse models of GBM have shown that delivery of this peptide effectively reduces stress-induced tumor progression, suggesting a novel peptide-based therapeutic strategy against refractory malignancies.

Other names

MSI1-C-terminus decoy peptidesMSI-1-C-terminus decoy peptidesMSI 1-C-terminus decoy peptides