mSIRK

mSIRK is a cell-permeable, myristoylated peptide that serves as a direct and specific activator of G-protein βγ (Gβγ) subunits. It is primarily utilized as a pharmacological research tool to investigate Gβγ-mediated signaling pathways independently of G-protein-coupled receptor (GPCR) activation. By binding to Gβγ subunits, mSIRK induces the dissociation of the Gαβγ heterotrimer, thereby triggering downstream effectors such as phospholipase C (PLC) and stimulating calcium influx from the extracellular space. In oncological research, particularly melanoma, mSIRK has been demonstrated to inhibit Epac-induced cell migration by modulating intracellular calcium dynamics and crosstalking with calmodulin-dependent pathways.

Other names

myristoylated SIRK peptideSIRK peptide