Drug intelligence / Profile preview

MSP-2009

Development stage
Preclinical
Lead developer
Taiho Pharmaceutical
Modality
Small Molecules
Administration
Intranasal
01

Overview

MSP-2009 is a proprietary, next-generation psychedelic small molecule developed by Mindset Pharma, which was acquired by Otsuka Pharmaceutical in 2023. It acts as a 5-HT2A receptor agonist and is designed as an optimized psilocybin analog, specifically belonging to Mindset's 'Family 2' portfolio of compounds. These molecules are engineered to offer improved pharmacological properties, such as increased potency and a potentially shorter duration of effect compared to first-generation psychedelics like psilocybin. MSP-2009 is being developed for the treatment of psychiatric disorders, including treatment-resistant depression (TRD) and post-traumatic stress disorder (PTSD), with the aim of providing a more predictable and scalable therapeutic option for patients.

Other names
MindSet Rx
02

Targets

HTR2A (Serotonin receptor 5-HT2A)

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