Drug intelligence / Profile preview

MT-009

Development stage: Preclinical
Lead developer: Marigold Therapeutics
Modality: Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous

Overview

MT-009 is a discovery-stage bispecific antibody-drug conjugate (Bs-ADC) being developed by Marigold Therapeutics. It is designed to target multiple antigens simultaneously to improve selectivity and efficacy in solid tumors, particularly those harboring Ras mutations. The drug is currently being investigated for the treatment of colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC), and non-small cell lung cancer (NSCLC). As a bispecific ADC, MT-009 likely utilizes a dual-targeting approach to enhance internalization and payload delivery to tumor cells while minimizing off-target toxicity.

Targets

KLRB1 (C-type lectin-like receptor CD161)

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