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MT-011
- Development stage
- Preclinical
- Lead developer
- Marigold Therapeutics
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Parenteral
01
Overview
MT-011 is a first-in-class bispecific antibody-drug conjugate (Bs-ADC) currently in the discovery phase of development by Marigold Therapeutics. The asset is designed to target two distinct antigens simultaneously, a strategy intended to enhance tumor selectivity and internalization of its cytotoxic payload while potentially reducing off-target toxicities associated with monospecific ADCs. MT-011 is being developed for the treatment of metastatic castration-resistant prostate cancer (mCRPC) and various other solid tumors. As a discovery-stage program, specific details regarding its target antigens, linker technology, and payload mechanism have not yet been publicly disclosed.
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