Drug intelligence / Profile preview

MT-6035

Development stage
Preclinical
Lead developer
Molecular Templates
Modality
Recombinant Proteins and Enzymes, Bacterial Toxin Conjugates → Immunotoxins → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

MT-6035 is an investigational **PD-L1-targeted engineered toxin body** developed by **Molecular Templates** for oncology indications. It is a biologic fusion toxin therapeutic built on the company's **engineered toxin body** platform and is designed to bind **programmed death-ligand 1**, deliver a cytotoxic toxin payload to **directly kill PD-L1-expressing tumor cells**, and incorporate **antigen seeding** to enhance redirection of T-cell responses against tumors. Based on the provided context, it was being advanced for both **solid tumors** and **hematologic malignancies**, with plans to submit an IND in the second half of 2019.

Other names
PD-L1-targeted engineered toxin bodyPD-L-1-targeted engineered toxin bodyPD-L 1-targeted engineered toxin bodyPD-L1-targeted ETBPD-L-1-targeted ETBPD-L 1-targeted ETB
02

Targets

CD274 (Programmed cell death protein 1 ligand 1)

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