MT-DADMe-ImmA

MT-DADMe‑ImmA is a synthetic small molecule and a transition-state analogue inhibitor of methylthioadenosine phosphorylase (MTAP). It is structurally related to Immucillin analogues and designed to mimic the transition state of the enzymatic reaction catalyzed by MTAP. By inhibiting this enzyme, it interferes with polyamine biosynthesis and methionine salvage pathways. This compound has been studied primarily as a biochemical tool for probing enzyme mechanisms and as a potential lead in anti-cancer drug development due to its ability to disrupt tumor cell metabolism dependent on MTAP activity. Its primary use remains experimental in nature.[1][9]

Other names

(3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL(3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)-4-(methylsulfanyl)methyl)pyrrolidin-3-ol653592–04–2