MT-Immucillin-H

MT‑Immucillin-H is a synthetic small molecule and a transition-state analogue inhibitor of purine nucleoside phosphorylase (PNP). It is structurally related to Immucillin-H but features a methylthio group. The compound mimics the transition state of the PNP-catalyzed reaction and binds tightly to the enzyme’s active site. By inhibiting PNP activity, it disrupts purine metabolism—an effect that can suppress T-cell proliferation and has been investigated for potential immunosuppressive or anticancer applications. Its primary use remains experimental.

Other names

(2S,3R,4S,5S)-3,4-Dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidinium(1S)-1-(0-deazahypoxanthin-9-YL)-1,4-dideoxy-1,4-imino–5-methylthio-D-ribitol