MTBhsp70-Avidin

MTBhsp70-Avidin (MAV) is a recombinant fusion protein biologic designed as a versatile, self-assembling vaccine platform. It consists of the 70 kDa heat shock protein from *Mycobacterium tuberculosis* (MtbHSP70) fused to avidin. The avidin component allows for the high-affinity, non-covalent binding of biotinylated antigenic peptides or proteins, while the MtbHSP70 portion acts as a potent molecular adjuvant. MtbHSP70 is known to stimulate the innate immune system via Toll-like receptors (specifically TLR2 and TLR4) and enhance the processing and presentation of associated antigens to T cells, thereby eliciting robust cellular immune responses. Developed as part of the VaxCelerate Project, this platform was engineered for rapid vaccine production against emerging infectious diseases, including Lassa fever and influenza.

Other names

Mycobacterium tuberculosis heat shock protein 70-avidin fusion protein