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Drug intelligence / Profile preview
MTBhsp70-Avidin
- Development stage
- Preclinical
- Lead developer
- Ligand Pharmaceuticals
- Modality
- Vaccines & Immunotherapeutics, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
01
Overview
MTBhsp70-Avidin (MAV) is a recombinant fusion protein biologic designed as a versatile, self-assembling vaccine platform. It consists of the 70 kDa heat shock protein from *Mycobacterium tuberculosis* (MtbHSP70) fused to avidin. The avidin component allows for the high-affinity, non-covalent binding of biotinylated antigenic peptides or proteins, while the MtbHSP70 portion acts as a potent molecular adjuvant. MtbHSP70 is known to stimulate the innate immune system via Toll-like receptors (specifically TLR2 and TLR4) and enhance the processing and presentation of associated antigens to T cells, thereby eliciting robust cellular immune responses. Developed as part of the VaxCelerate Project, this platform was engineered for rapid vaccine production against emerging infectious diseases, including Lassa fever and influenza.
- Other names
- Mycobacterium tuberculosis heat shock protein 70-avidin fusion protein
02
Targets
TLR2 (Toll-like Receptor 2)TLR4 (Toll-like receptor 4)
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