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MTI-301-N
- Development stage
- Preclinical
- Lead developer
- Modulation Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
MTI-301-N is an orally administered small molecule inhibitor of stearoyl-CoA desaturase 1 (SCD-1) being developed by Modulation Therapeutics. SCD-1 is a rate-limiting lipogenic enzyme responsible for the synthesis of monounsaturated fatty acids, specifically oleate and palmitoleate, from saturated fatty acids. By inhibiting this enzyme, MTI-301-N aims to reduce hepatic steatosis and improve insulin sensitivity, addressing the underlying pathology of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). While a related variant, MTI-301-C, is being investigated for advanced solid tumors, MTI-301-N is specifically positioned for metabolic liver diseases and is currently in the preclinical stage of development.
- Other names
- MTI-301MTI301MTI 301
02
Targets
SCD1 (Stearoyl-CoA desaturase 1)
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