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MTL-STING
- Development stage
- Preclinical
- Lead developer
- MiNA Therapeutics
- Modality
- RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral, Subcutaneous
01
Overview
MTL-STING is a small activating RNA (saRNA) therapeutic developed by MiNA Therapeutics for the treatment of solid tumors. It functions as a STING agonist, specifically designed to upregulate the expression of the STING protein and activate downstream innate immune pathways. By restoring endogenous STING expression—which is often downregulated in cancer as an immune evasion mechanism—MTL-STING aims to improve the efficacy of existing anti-cancer therapies and enhance the innate immune response against tumors[1][2][3]. The drug is currently being evaluated in preclinical studies and IND-enabling studies, with initial development focused on combination therapy for solid tumor malignancies[1][3].
- Other names
- MTL STING
02
Targets
STING (Stimulator of interferon genes protein)
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