Drug intelligence / Profile preview

MTP-101

Development stage
Phase 2
Lead developer
Gut-Brain Axis Therapeutics
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral, Rectal, Colonic
01

Overview

**MTP-101** is an investigational oral microbiome therapy based on healthy-donor fecal microbiota transplantation. Public sources show that the exact umbrella code \"MTP-101\" is used across at least two formulation-specific products: **MTP-101-C**, an encapsulated fecal microbiota product, and **MTP-101P**, a purified freeze-dried powder formulation. These products are being studied in conditions linked to gut dysbiosis and immune dysfunction, including immune-mediated colitis, immune-related dermatitis, hepatic encephalopathy, and Pitt-Hopkins syndrome with gastrointestinal symptoms. Mechanistically, MTP-101 is intended to restore a disrupted intestinal microbial community, promote donor-bacteria engraftment, suppress pathobionts, and modulate local and systemic immune signaling rather than act through a single defined molecular target. Because the query is exactly \"mtp-101\" rather than a formulation-specific code, the most accurate annotation is as a non-specific parent microbiota-transfer product family rather than one uniquely defined finished drug product.

Other names
microbiota transfer therapyMTT

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