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MTX240

Development stage: Unknown
Lead developer: Biodexa Pharmaceuticals
Modality: Molecular Glues → Targeted Protein Degraders (TPDs) → Small Molecules

Overview

MTX240 (formerly OPB-171775) is a Phase 1-ready molecular glue being developed by Biodexa Pharmaceuticals under an exclusive global license (excluding Japan) from Otsuka Pharmaceutical. The drug is specifically designed for the treatment of gastrointestinal stromal tumors (GIST), with a focus on patients who have developed resistance to standard-of-care tyrosine kinase inhibitors (TKIs). MTX240 operates through a novel mechanism of action that is independent of KIT signaling, addressing a significant unmet need for patients with TKI-refractory disease. This KIT-independent approach aligns with Biodexa's strategic focus on rare diseases and its oncology pipeline, while Otsuka retains development and commercialization rights in Japan.

Other names: OPB-171775OPB171775OPB 171775

Targets

PDE3A–SLFN12 (Phosphodiesterase 3A–Schlafen family member 12 protein–protein interface)

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