Drug intelligence / Profile preview

Mu Ji Fang

Development stage
Unknown
Lead developer
The First Affiliated Hospital of Guangxi Medical University
Modality
Small Molecules
Administration
Oral
01

Overview

Mu Ji Fang (MJF) is a Traditional Chinese Medicine (TCM) formulation, primarily administered as granules, that has been used clinically in China for over 30 years to treat hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). The formula contains a complex mixture of active ingredients, including alkaloids, flavonoids, and polysaccharides. Research indicates that MJF exerts anti-tumor effects by inducing apoptosis in cancer cells and suppressing immune escape mechanisms. Its molecular mechanism involves the inhibition of the Transforming Growth Factor-beta 1 (TGF-β1)/Smad signaling pathway, which is a key driver of fibrosis and tumor progression in the liver. MJF is often utilized as a complementary or primary therapy in regional Chinese clinical settings for chronic liver diseases.

Brand names
Mu Ji Fang Granules
Other names
MJF granulesMuji Formula
02

Targets

TGFB1 (Transforming growth factor Beta-1 proprotein)SMAD (SMAD family)

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