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MUC1-targeted CAR-T cells (Zhujiang Hospital)
- Development stage
- Unknown
- Lead developer
- Southern Medical University Zhujiang Hospital
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
This is an experimental chimeric antigen receptor T-cell (CAR-T) therapy developed by Zhujiang Hospital of Southern Medical University for the treatment of relapsed or refractory acute myeloid leukemia (AML). The therapy involves genetically engineering a patient's own T cells to express a chimeric antigen receptor that specifically recognizes MUC1 (Mucin 1), a glycoprotein often aberrantly expressed on the surface of AML cells. By targeting MUC1, these CAR-T cells are designed to selectively identify and eliminate leukemic cells while sparing normal tissues. This therapy is being evaluated as part of a broader clinical strategy (NCT03473457) that explores various antigen targets, including CD33, CD38, and CD123, to address the heterogeneity and antigen escape common in AML.
- Other names
- anti-MUC1 CAR-Tanti-MUC-1 CAR-Tanti-MUC 1 CAR-TMUC1-specific CAR-T cellsMUC-1-specific CAR-T cellsMUC 1-specific CAR-T cells
02
Targets
MUC1 (Mucin-1 Antigen)
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