mucosal influenza vaccine

Mucosal influenza vaccines are a class of prophylactic agents designed to elicit immune responses at the mucosal surfaces where the influenza virus typically enters the body, such as the respiratory or gastrointestinal tract. Unlike traditional injectable vaccines that primarily stimulate systemic IgG antibodies, mucosal vaccines are engineered to induce local secretory IgA (sIgA) and cellular immune responses in addition to systemic immunity. This dual-layered protection can potentially block viral entry and shedding more effectively, thereby reducing transmission. Administration routes include intranasal sprays, such as the live-attenuated influenza vaccine (LAIV) FluMist, and experimental oral formulations like tablet-based platforms. Various technologies are employed in this space, including live-attenuated viruses, viral vectors (such as adenovirus), and protein subunits combined with specialized mucosal adjuvants or delivery systems like nanoparticles.

Brand names

FluMistFluenzNasovac

Other names

intranasal influenza vaccineoral influenza vaccinenasal influenza vaccine