Drug intelligence / Profile preview

mulberry leaf water extract

Development stage
Unknown
Lead developer
Phynova
Administration
Oral
01

Overview

Mulberry leaf water extract is an aqueous extract of the leaves of the Morus alba plant, standardized in some commercial preparations (such as Reducose) for specific bioactive components like 1-deoxynojirimycin (DNJ)[3]. It is used for its reported hypoglycemic, antioxidant, anti-obesity, and lipid-lowering effects, with actions that include inhibition of carbohydrate digestion enzymes (notably alpha-glucosidase), modulation of mitochondrial function through the AMPK pathway, and increased reactive oxygen species scavenging[1][3][4]. These mechanisms underlie its investigation as a functional food ingredient, dietary supplement, or adjunctive therapy for type 2 diabetes mellitus, metabolic syndrome, obesity, and related disorders. The primary active constituents identified include polysaccharides, alkaloids (such as DNJ), flavonoids, and phenolic acids[3][4].

Brand names
Reducose
Other names
mulberry leaf aqueous extractmulberry leaf extract (water extract)MLE (mulberry leaf extract, unspecified solvent)MLQE (mulberry leaf aqueous extract)
02

Targets

Sucrase-IsomaltaseAMPK (Adenosine monophosphate–activated protein kinase)

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