multi-allergen oral immunotherapy

Multi-allergen oral immunotherapy (Multi OIT) is an investigational therapeutic approach designed to desensitize individuals allergic to multiple foods simultaneously. Unlike single-allergen OIT, this protocol involves the concurrent administration of gradually increasing doses of several food proteins—such as peanut, milk, egg, wheat, and various tree nuts—to induce immunological tolerance. The treatment aims to shift the immune response away from an IgE-mediated allergic reaction, thereby increasing the threshold for allergic triggers and reducing the risk of anaphylaxis. Multi OIT is often evaluated in clinical trials alongside adjunctive therapies like omalizumab (an anti-IgE monoclonal antibody) to facilitate a more rapid and safer dose escalation. It is primarily researched in academic and clinical settings, notably at the Sean N. Parker Center for Allergy & Asthma Research at Stanford University.

Other names

Multi OITmulti-food oral immunotherapymultiple food allergen oral immunotherapyMulti-allergen OIT