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Multi-Characteristic Opsin (Nanoscope Technologies)
- Development stage
- Unknown
- Lead developer
- Nanoscope Therapeutics
- Modality
- Gene Therapies, Nanoparticles → Drug Delivery Systems
- Administration
- Intrathecal
01
Overview
**Multi-Characteristic Opsin** is an investigational optogenetic gene-therapy payload being developed for non-opioid treatment of chronic pain. The program uses non-viral, nano-enhanced optical delivery of DNA encoding MCO to selectively sensitize pain-blocking inhibitory neurons in the spinal cord and related pain pathways. Following expression, red LED light activates the light-sensitive opsin, depolarizing targeted inhibitory neurons to suppress pain signaling while avoiding nonspecific electrical stimulation of surrounding neurons. Delivery approaches described publicly use functionalized gold nanorods, low-power laser-mediated gene delivery, and cell-selective promoters. ([nanoscopetech.com](https://www.nanoscopetech.com/technologies))
- Other names
- MCO
02
Targets
GRM6 (mGluR6)
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