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multi-epitope HER2 peptide vaccine H2NVAC
- Development stage
- Phase 1
- Lead developer
- Mayo Clinic
- Modality
- Peptides, Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
H2NVAC is a multi-epitope T helper cell-activating peptide vaccine composed of four immunogenic epitopes derived from the tumor-associated antigen human epidermal growth factor receptor 2 (HER2). It is designed to stimulate specialized white blood cells, thereby increasing immune response and providing protection against breast cancer. The vaccine is admixed with GM-CSF as an adjuvant. Clinical trials have shown that H2NVAC generates robust, long-lasting T and B cell immune responses. Its primary indication is for the treatment of HER2-expressing ductal carcinoma in situ and residual disease after neoadjuvant chemotherapy in HER2-positive breast cancer[1][3][4][5].
- Other names
- multi-epitope HER2 peptide vaccine
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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