Drug intelligence / Profile preview

multibotanical preparation

Development stage
Discontinued
Lead developer
Kaiser Permanente
Administration
Oral
01

Overview

The multibotanical preparation (Kaiser Permanente) is a complex herbal supplement formulated specifically for the Herbal Alternatives for Menopause (HALT) study. It consists of ten components: black cohosh (50 mg), alfalfa, chaste tree, dong quai, false unicorn, licorice, oats, pomegranate, Siberian ginseng, and boron. Administered as four capsules daily (200 mg total daily dose), the preparation was intended to treat vasomotor symptoms, including hot flashes and night sweats, in peri- and postmenopausal women. A randomized, double-blind, placebo-controlled trial conducted between 2001 and 2004 involving 351 women aged 45-55 years found that the preparation was no more effective than placebo in reducing symptom frequency or severity. Furthermore, the study demonstrated that the preparation had no significant impact on reproductive hormones, vaginal epithelium, or the endometrium.

Other names
HALT multibotanical preparationHerbal Alternatives for Menopause multibotanical
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)LDLR (Low-density lipoprotein receptor)PCSK9 (Proprotein convertase subtilisin/kexin type 9)SREBP-2 / SREBF2 (SREBP-2)

Beyond the preview

Go deeper on multibotanical preparation.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on multibotanical preparation.

Gosset Free

Get started with Gosset.

Enter your corporate email.

Work email preferred.

Book a call