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MultiPlex In Vivo CAR-T
- Development stage
- Preclinical
- Lead developer
- Chimeron Bio
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies, Nanoparticles → Drug Delivery Systems, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Injection
01
Overview
MultiPlex In Vivo CAR-T is an investigational gene therapy platform being developed by Chimeron Bio for the treatment of various cancers. This approach utilizes the company's proprietary ChaESAR™ (Chimeric Enhanced Self-Amplifying RNA) technology delivered via the MultiPlex nanoparticle system. Unlike traditional CAR-T cell therapies that require complex ex vivo manufacturing—where a patient's T cells are extracted, modified in a lab, and reinfused—this therapy is designed to genetically reprogram T cells directly within the patient's body through a simple injection. By delivering self-amplifying mRNA (saRNA) constructs in vivo, the platform enables the expression of Chimeric Antigen Receptors (CARs), including dual-target designs, to drive immune-mediated elimination of cancer cells while potentially increasing patient access and reducing treatment complexity.
- Other names
- Chimeron Bio in vivo CAR-TMultiPlex gene delivery CAR-T
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