multiprofen-cc

Multiprofen-CC is a multimodal topical cream formulated for the management of localized musculoskeletal pain, particularly in patients undergoing procedures such as total knee arthroplasty. It contains four active pharmaceutical ingredients: ketoprofen (10%), a non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis; baclofen (5%), a GABA-B receptor agonist and muscle relaxant; amitriptyline (2%), a tricyclic antidepressant with analgesic properties likely mediated by inhibition of norepinephrine and serotonin reuptake; and lidocaine (5%), a local anesthetic that blocks sodium channels to prevent nerve depolarization. The combination targets multiple pain pathways, aiming to provide enhanced analgesia while potentially reducing opioid requirements post-surgery. Multiprofen-CC is compounded for individual patients rather than mass-produced, with each ingredient approved by Health Canada[1][2][3][4][5].

Brand names

Multiprofen-CC

Other names

Multiprofen-CC