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multivalent mRNA pancoronavirus vaccine
- Development stage
- Preclinical
- Lead developer
- BioNet
- Modality
- Vaccines & Immunotherapeutics, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
01
Overview
BioNet, in collaboration with a global consortium and supported by the Coalition for Epidemic Preparedness Innovations (CEPI), is developing a multivalent mRNA vaccine prototype aimed at providing broad cross-protective immunity against various coronaviruses. The vaccine utilizes a "plug-and-play" mRNA platform to deliver multiple mRNA molecules that encode several target proteins (immunogens) from different SARS-CoV-2 variants and potentially other betacoronaviruses like MERS-CoV. These mRNA sequences are encapsulated in lipid nanoparticles (LNPs) for delivery. The project's goal is to create a broadly protective vaccine capable of addressing current SARS-CoV-2 variants and future pandemic threats, often referred to as "Disease X."
- Other names
- pancoronavirus mRNA vaccine prototypeBioNet multivalent mRNA vaccinemultivalent mRNA vaccine (pancoronavirus prototype)
02
Targets
SARS-CoV-2 spike
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