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mumps virus RIT 4385 strain
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Live Attenuated Vaccines → Live Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Subcutaneous, Intramuscular
01
Overview
Mumps virus RIT 4385 strain is a live-attenuated virus used as the mumps component in several vaccines developed by GSK, including Priorix (MMR) and Priorix-Tetra (MMRV). It was derived from the Jeryl Lynn strain, specifically cloned from the JL-5 isolate to ensure genetic stability and consistent immunogenicity. The strain functions by inducing a robust immune response, including the production of neutralizing antibodies and T-cell activation, providing long-term protection against mumps infection. It is manufactured using chicken embryo fibroblast cells and is typically administered as part of a combination vaccine to prevent measles, mumps, and rubella.
- Other names
- RIT4385RIT-4385RIT 4385Mumps RIT 4385
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