mupirocin

Mupirocin is a naturally occurring topical antibiotic derived from *Pseudomonas fluorescens*, primarily used to treat superficial skin infections such as impetigo, folliculitis, and secondary traumatic skin lesions caused by susceptible bacteria including *Staphylococcus aureus* (including MRSA) and *Streptococcus pyogenes*. It is also used intranasally for the eradication of nasal carriage of MRSA. Mupirocin acts by reversibly inhibiting bacterial isoleucyl-tRNA synthetase, leading to inhibition of protein synthesis and ultimately bacteriostasis or bactericidal effects at higher concentrations. It does not exhibit cross-resistance with other classes of antibiotics due to its unique mechanism. Mupirocin is available only in topical formulations because it undergoes rapid systemic metabolism. Common side effects include local irritation such as burning, stinging, or itching at the application site[1][2][3][4][5].

Brand names

BactrobanCentany

Other names

pseudomonic acid Amupirocinemupirocin calciumpseudomonic acid