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Muscle Targeted AOC
- Development stage
- Preclinical
- Lead developer
- Aera Therapeutics
- Modality
- Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Muscle Targeted AOC is an investigational antibody-oligonucleotide conjugate (AOC) being developed by Aera Therapeutics. The program is designed to deliver oligonucleotide therapeutics selectively to muscle tissue, aiming to treat diseases affecting the muscular system. By utilizing a targeting antibody conjugated to an oligonucleotide payload, the therapy seeks to overcome the delivery challenges typically associated with systemic administration of genetic medicines. As of early 2024, the program is in the discovery stage, and specific molecular targets or clinical indications have not been disclosed.
- Other names
- Aera Therapeutics muscle targeted AOCMuscle Targeted AOC (Aera Therapeutics)
02
Targets
TFRC (Transferrin Receptor)
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