Drug intelligence / Profile preview

MVA-209-FSP

Development stage: Unknown
Lead developer: Nouscom
Modality: Viral Vectors → Gene Addition/Replacement → Gene Therapies, Vaccines & Immunotherapeutics
Administration: Intramuscular

Overview

MVA-209-FSP is an off-the-shelf neoantigen boosting vaccine comprised of a modified Vaccinia virus Ankara (MVA) encoding tumor-specific neoantigens (TSNAs). It is specifically designed for patients with microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) cancers. The vaccine consists of four MVA vectors (MVA-209-FSP-B1, MVA-209-FSP-B2, MVA-209-FSP-B3, and MVA-209-FSP-B4), each encoding a synthetic polyepitope consisting of cancer-specific Frame Shift Peptides (FSPs) joined head to tail. MVA-209-FSP is used as the boosting component in the Nous-209 heterologous prime/boost regimen, following priming with GAd20-209-FSP.

Other names: MVA tumor-specific neoantigen boosting vaccine MVA-209-FSP

Targets

MHC II (Major histocompatibility complex class II receptor)CD3 (T-cell surface glycoprotein CD3)Frameshift peptide neoantigens

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