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MVA-CN54
- Development stage
- Unknown
- Lead developer
- Imperial College London
- Modality
- Viral Vector Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
MVA-CN54 is an experimental HIV vaccine candidate based on the Modified Vaccinia Ankara (MVA) viral vector platform. It expresses HIV-1 subtype C (CN54)-derived antigens, specifically the envelope glycoprotein gp120 (Env), as well as Gag, Pol, and Nef polyproteins. The vaccine is designed to induce both cellular and humoral immune responses against HIV-1 by presenting these antigens to the immune system. MVA-CN54 has been evaluated in phase 1 clinical trials as part of prime-boost regimens for prophylactic vaccination against HIV infection[1][3]. The primary developer is Imperial College London[2][3].
- Other names
- Modified Vaccinia Ankara-CMVA-C (97CN54)MVA-C (nominal titre)
02
Targets
Gag (HIV-1 Gag polyprotein)Nef (HIV-1 Nef)Human immunodeficiency virus type 1 reverse transcriptasegp120 (HIV-1 envelope glycoprotein (gp120/gp41) epitopes)
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