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MVA-SARS-2-S
- Development stage
- Phase 2
- Lead developer
- University Medical Center Hamburg-Eppendorf
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
MVA-SARS-2-S is an investigational COVID-19 vaccine candidate that uses a Modified Vaccinia Virus Ankara (MVA) vector to express the full-length spike (S) protein of SARS-CoV-2. The MVA vector is a highly attenuated, non-replicating poxvirus with a strong safety profile in mammalian hosts. Upon intramuscular administration, the vaccine delivers the SARS-CoV-2 S protein, inducing both humoral and cellular immune responses, including neutralizing antibodies and CD8+ T cells specific for the spike antigen. Preclinical studies have shown that vaccination with MVA-SARS-2-S protects animals from lethal SARS-CoV-2 infection and severe lung pathology by eliciting robust immune responses[1][4][5]. The primary indication is prevention of COVID-19.
- Other names
- Modified Vaccinia virus Ankara-SARS-CoV-2-Spike
02
Targets
SARS-CoV-2 spike
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