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MVP-104-BsAb
- Development stage
- Preclinical
- Lead developer
- Multiverse Pharma
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
MVP-104-BsAb is a preclinical-stage bispecific antibody developed by Multiverse Pharma for the treatment of metastatic brain cancers. The drug is derived from the company's proprietary MVP-104 Blood-Brain Barrier (BBB) Shuttle platform, which is designed to facilitate the transport of therapeutic biologics across the BBB into the central nervous system. MVP-104-BsAb specifically targets the Insulin-like Growth Factor 1 Receptor (IGF-1R), a tyrosine kinase receptor that plays a critical role in tumor cell proliferation, survival, and resistance to apoptosis in various malignancies. By integrating a BBB-crossing mechanism with IGF-1R inhibition, MVP-104-BsAb aims to provide a targeted therapeutic option for patients with brain metastases, addressing the significant challenge of drug delivery to the brain.
- Other names
- MVP-104-Multispecific EngagerMVP104-Multispecific EngagerMVP 104-Multispecific Engager
02
Targets
IGF-1R (Insulin-like growth factor 1 receptor)
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