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MVT-2401

Development stage: Preclinical
Lead developer: Microviable Therapeutics
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics

Overview

MVT-2401 is a rationally designed, defined bacterial consortium being developed by Microviable Therapeutics as a microbial immunotherapy to enhance the efficacy of immune checkpoint inhibitors in solid tumors. It comprises 12 proprietary commensal strains selected bioinformatically and validated in vitro for immuno-oncology–relevant traits, with the aim of modulating the gut microbiome and systemic antitumor immunity to potentiate responses to anti‑PD‑1 and CTLA‑4 therapies.[1]

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