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mWOTS-418
- Development stage
- Unknown
- Lead developer
- Bionoxx
- Modality
- Oncolytic Viruses → Oncolytic Therapeutics, Gene Therapies
- Administration
- Intranasal
01
Overview
mWOTS-418 is an engineered oncolytic vaccinia virus developed by Bionoxx as part of its mOTS-400s series. The virus is designed to selectively infect and replicate within tumor cells, leading to their destruction through direct lysis and the induction of a systemic anti-tumor immune response. It is specifically engineered to express a truncated or mutant version of the Herpes Simplex Virus Thymidine Kinase (HSV-TK) gene. This modification is intended to enhance the virus's tumor-selective killing capabilities and may allow for the use of nucleoside analogs as a safety switch or to provide additional cytotoxic effects. As of the current pipeline, mWOTS-418 is in the discovery phase for undisclosed oncology indications.
- Other names
- mWOTS-418mWOTS418mWOTS 418
02
Targets
HSV-TK (Herpes simplex virus type 1 thymidine kinase (HSV1-TK))
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