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MWX203 S5

Development stage: Unknown
Lead developer: Shanghai Minwei Biotechnology
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Subcutaneous

Overview

MWX203 (also written as MWX-203) is an investigational small interfering RNA (siRNA) therapeutic developed by Shanghai Minwei Biotechnology, a subsidiary of Lepu Medical Technology. It is designed to target angiopoietin-like 3 (ANGPTL3) for the treatment of dyslipidemia, mixed dyslipidemia, and hyperlipidemia. By utilizing RNA interference (RNAi) to inhibit the expression of ANGPTL3, MWX203 aims to lower blood lipid levels, including triglycerides and low-density lipoprotein cholesterol (LDL-C). The drug is administered via subcutaneous injection and is currently in Phase 2 clinical development.

Targets

ANGPTL3 (Angiopoietin-like protein 3)ASGPR (Asialoglycoprotein Receptor 1)

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