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MYCO-005

Development stage
Preclinical
Lead developer
Mydecine Innovations Group
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral, Transdermal
01

Overview

MYCO-005 is a novel, second-generation psychedelic hallucinogen and a serotonin 5-HT2A receptor agonist, developed by Mydecine Innovations Group. It is an aza-indole analogue of psilocin, engineered to provide an improved safety profile by avoiding binding to the serotonin 5-HT2B receptor, which is associated with cardiac valvulopathy. This selective binding aims to make MYCO-005 heart-safe for both macro- and microdosing applications. The drug is under development for the treatment of depressive disorders, anxiety disorders, and posttraumatic stress disorder (PTSD). Mydecine is also exploring a patent-pending dermal route of administration for a low-dosed, time-released, non-hallucinatory patch formulation.

Other names
aza-indole analogue of psilocinaza-substituted psilocin analoguesnovel aza psilocin analoguepsilocin analog
02

Targets

HTR2A (Serotonin receptor 5-HT2A)

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