Drug intelligence / Profile preview

mycophenolate mofetil + phosphodiesterase 5 inhibitors + carnitine

Development stage
Unknown
Lead developer
Roche
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

This is a combination of three distinct agents, each with its own mechanism and indication. Mycophenolate mofetil is an immunosuppressant used to prevent organ transplant rejection by inhibiting inosine monophosphate dehydrogenase (IMPDH), thereby blocking lymphocyte proliferation. Phosphodiesterase 5 (PDE5) inhibitors are a class of drugs that increase blood flow by inhibiting the breakdown of cyclic guanosine monophosphate (cGMP), commonly used for erectile dysfunction and pulmonary arterial hypertension. Carnitine is a naturally occurring compound involved in fatty acid metabolism, often supplemented to treat or prevent deficiency, especially in patients with kidney disease on dialysis.

Other names
MMF + PDE5 inhibitors + carnitinemycophenolate mofetil plus phosphodiesterase 5 inhibitors plus carnitine
02

Targets

IMPDH (Inosine-5'-monophosphate dehydrogenase 1)

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