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mycophenolate mofetil + prednisone
- Development stage
- Preclinical
- Lead developer
- Roche
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination immunosuppressive therapy consisting of mycophenolate mofetil and prednisone. **Mycophenolate mofetil (MMF)** is a prodrug of mycophenolic acid that inhibits inosine monophosphate dehydrogenase (IMPDH), thereby suppressing T and B lymphocyte proliferation. **Prednisone** is a corticosteroid that reduces inflammation through multiple mechanisms. This combination has shown effectiveness in treating retroperitoneal fibrosis and autoimmune conditions like ITP (immune thrombocytopenia). The typical regimen involves prednisone 40 mg daily with gradual tapering over 6 months, combined with mycophenolate mofetil 1000 mg twice daily.
- Other names
- corticosteroid + mycophenolatemycophenolate mofetil with corticosteroidsMMF + prednisoneprednisone + MMF
02
Targets
GR (Glucocorticoid receptor)IMPDH (Inosine-5'-monophosphate dehydrogenase 1)
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