Mycro-3

Mycro-3 is a small molecule inhibitor of the c-Myc oncoprotein. It specifically targets the protein-protein interaction between c-Myc and its obligate dimerization partner, Max. By disrupting the formation of the Myc-Max heterodimer, Mycro-3 prevents the complex from binding to DNA and activating the transcription of genes involved in cell proliferation, metabolism, and survival. In the context of oncology research, Mycro-3 has been shown to reverse chemoresistance in prostate cancer by interrupting a metabolic loop involving tryptophan metabolism (TDO2/Kyn/AhR/c-Myc). This inhibition leads to the downregulation of ATP-binding cassette (ABC) transporters and solute carrier (SLC) transporters, thereby increasing the intracellular accumulation and efficacy of chemotherapeutic agents like docetaxel and abiraterone.

Other names

Mycro 3Mycro3Mycro-3