Mydrane

Mydrane is an intracameral injectable solution used in cataract surgery to obtain mydriasis (pupil dilation) and intraocular anesthesia during the surgical procedure. It contains a combination of two mydriatics (tropicamide 0.02% and phenylephrine 0.31%) and one anesthetic (lidocaine hydrochloride 1%)[1][8]. ## Composition and Dosage One dose (0.2 ml) of Mydrane contains: - 0.04 mg of tropicamide - 0.62 mg of phenylephrine hydrochloride - 2 mg of lidocaine hydrochloride monohydrate[6] The solution is administered by intracameral injection at the beginning of cataract surgery, eliminating the need for preoperative mydriatic eye drops[1][9]. ## Clinical Benefits Mydrane offers several advantages over traditional topical mydriatic administration: - Eliminates the preoperative dilation phase, reducing overall patient care time[4][9] - Provides rapid and stable mydriasis for the duration of cataract surgery[1] - Offers intraocular anesthesia during the procedure[1] - Reduces the risk of systemic side effects due to lower concentrations of active substances[8] ## Administration Mydrane is administered by an ophthalmic surgeon as a single intracameral injection of 0.2 ml into the anterior chamber of the eye through the side port or principal port at the start of the surgical procedure[1]. It should only be used in patients who have demonstrated satisfactory pupil dilation with topical mydriatic therapy during preoperative assessment[1]. ## Safety Information Mydrane is not recommended for: - Combined cataract surgery with vitrectomy - Patients with a shallow anterior chamber - Patients with a history of acute increase in eye pressure[2] The product contains less than 1 mmol sodium (23 mg) per dose, making it essentially "sodium-free"[2]. ## Availability Mydrane is supplied in boxes containing 20 sterile ampoules and 20 sterile filter needles. It is a hospital-only product with an NHS price of £119.95 per box[1]. ## Regulatory Status Mydrane has Marketing Authorization for cataract surgery to obtain mydriasis and intraocular anesthesia during the surgical procedure in adults[4]. It has demonstrated non-inferiority compared to standard pupil dilation protocols that include instillation of mydriatics in the form of eye drops[4].

Brand names

Mydrane

Other names

Lidocaine/phenylephrine/tropicamideMydaneTropicamide/Lidocaine/Phenylephrine