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MYJ1633-SCSa

Development stage: Unknown
Lead developer: IMMUNISBIO
Modality: CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intraperitoneal

Overview

MYJ1633-SCSa is an autologous natural killer (NK) cell therapy developed by IMMUNISBIO for the treatment of peritoneal metastasis in gastrointestinal cancer. The therapy utilizes the patient's own NK cells, which are expanded and activated ex vivo to enhance their cytotoxic potential against malignant cells. MYJ1633-SCSa is administered via intraperitoneal (IP) injection, a route designed to deliver the therapeutic cells directly into the peritoneal cavity where the metastatic lesions reside, potentially overcoming the limitations of systemic delivery. A Phase 1/2a clinical trial investigating the safety and efficacy of MYJ1633-SCSa monotherapy commenced in the first quarter of 2024.

Targets

FCGR3A (Low affinity immunoglobulin gamma Fc region receptor III-A)NCR1 (Natural cytotoxicity triggering receptor 1)

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