MyoTRIM

MyoTRIM is an engineered recombinant version of the human Tripartite motif protein 72 (TRIM72), also known as mitsugumin 53 (MG53), designed for the treatment of muscular dystrophies. It is specifically modified with amino acid replacements that eliminate the E3 ligase activity of the wild-type protein—thereby reducing potential metabolic side effects—and improve its solubility while preserving its essential membrane-repair functions. MyoTRIM facilitates the repair of the sarcolemma (the muscle cell membrane) following injury, a process that is compromised in conditions like Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). Preclinical studies in cell and mouse models have demonstrated its ability to enhance membrane integrity and protect against contraction-induced muscle damage.

Other names

modified rhMG53modified TRIM72modified mitsugumin 53