Drug intelligence / Profile preview

myrica esculenta extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

*Myrica esculenta extract* is a **plant-derived extract** from the leaves, bark, and fruits of Myrica esculenta (box myrtle/kaphal), used in ethnomedicine and investigated for its diverse pharmacological effects. The extracts contain a range of bioactive compounds such as **phenolic acids** (gallic acid, p-coumaric acid), **flavonoids** (myricetin, quercetin, catechin), **diarylheptanoids** (myricanol, myricanone), **triterpenoids** (oleanolic acid, lupeol), and **steroids** (β-sitosterol, stigmasterol). Key mechanisms include **antioxidant activity** through radical scavenging, **antimicrobial** effects against Gram-positive and Gram-negative bacteria, **anti-inflammatory** action, and **angiotensin-converting enzyme (ACE) inhibition**, suggesting possible antihypertensive activity. The extract's mechanism of action is multifactorial and is attributed to its phytochemical composition, especially the phenolics, flavonoids, and terpenoids, which modulate oxidative stress, inflammation, and the microbial membrane[1][3][4].

Brand names
myrica esculenta extract
Other names
box myrtle extractkaphal extractmethanolic myrica esculenta extractethanolic myrica esculenta extractaqueous myrica esculenta extractmyrica esculenta leaf extractmyrica esculenta bark extract
02

Targets

ACE (Angiotensin Converting Enzyme)ATP4A (Potassium–transporting ATPase alpha chain 1)HRH2 (Histamine H2 Receptor)

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