myricetin

Myricetin is a naturally occurring flavonoid belonging to the flavonol class of polyphenolic compounds. It is widely found in various plants, including medicinal herbs, vegetables, berries, and tea leaves[1][5][7]. Myricetin exhibits diverse biological activities such as antioxidant, anticancer, antidiabetic, anti-inflammatory, and immunomodulatory effects[2][3][4]. Mechanistically, it acts as a potent free radical scavenger at low concentrations but can display pro-oxidant effects at higher doses[2]. Myricetin has been shown to inhibit angiogenesis by downregulating VEGF secretion via the Akt/p70S6K/HIF-1α pathway and induce apoptosis in cancer cells through mitochondrial pathways[3][8]. In neurological models (e.g., multiple sclerosis), it promotes Nrf2-mediated antioxidative signaling and supports myelination[5]. Recent studies indicate that myricetin inhibits human Uba1 (ubiquitin-like modifier activating enzyme 1) by binding to its ATP-binding site and blocking ubiquitin transfer—suggesting potential for cancer therapy targeting protein ubiquitination pathways[6].

Other names

3,3',4',5,5',7-hexahydroxyflavone