Drug intelligence / Profile preview

Myristica fragrans fruit

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Myristica fragrans fruit refers to the fruit of the nutmeg tree, an evergreen species native to the Maluku Islands of Indonesia. This fruit is the source of two well-known spices: nutmeg (the dried seed) and mace (the dried aril or seed covering). Beyond its culinary uses, Myristica fragrans has a long history in traditional medicine systems, including Ayurvedic, Chinese, and European folk medicine. It is recognized for a wide array of potential therapeutic properties, such as anti-inflammatory, analgesic, antioxidant, antimicrobial, and sedative effects. Its psychoactive properties, particularly at high doses, are attributed to key bioactive compounds like myristicin, safrole, and elemicin. Myristicin, for instance, is known to act as a monoamine oxidase inhibitor. Other compounds like eugenol contribute to its antifungal and anti-inflammatory actions, while macelignan has shown anti-microbial, anti-cancer, antidiabetic, hepatoprotective, and neuroprotective effects. The fruit and its extracts are also explored for their potential in improving cognitive function, aiding digestion, and acting as an aphrodisiac.

Other names
NutmegMaceCommon nutmegTrue nutmegFragrant nutmegJaiphal
02

Targets

MAOB (Monoamine oxidase B)MAOA (Monoamine oxidase A)

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