Drug intelligence / Profile preview

MyVaccx

Development stage
Unknown
Lead developer
The Center for High Risk and Recurrent Cancer
Modality
Device-based Delivery → Drug Delivery Systems, Cytokines & Interferons → Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intratumoral, Subcutaneous
01

Overview

MyVaccx is an experimental personalized immunotherapy regimen developed by Dr. Gary Onik for the treatment of various adenocarcinomas, including prostate and pancreatic cancers. The protocol employs a multi-modal approach designed to create an *in situ* tumor vaccine. It begins with cryosurgical ablation of a portion of the tumor to induce cell death and release tumor-specific antigens. This is immediately followed by the intratumoral injection of two checkpoint inhibitors, ipilimumab (Yervoy) and pembrolizumab (Keytruda), to counteract local immune suppression. The regimen is completed with a two-month course of systemic sargramostim (Leukine), a recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF), to stimulate and amplify the systemic immune response against the released antigens.

Other names
MyVaccx immunotherapy regimenOnik immunotherapy protocolimmunotherapeutic agents-Gary Onik MD-adenocarcinoma
02

Targets

CSF2R (Granulocyte-macrophage colony-stimulating factor receptor)PDCD1 (Programmed cell death protein 1 receptor)CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)

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