Drug intelligence / Profile preview

MZ-01

Development stage
Unknown
Lead developer
Chengdu Mizi Biopharmaceutical Technology
Modality
Small Molecules
Administration
Inhalation
01

Overview

MZ-01 is an innovative inhalation solution developed by Chengdu Mizi Biopharmaceutical Technology for the prevention of postoperative pulmonary complications (PPC) in the perioperative period. PPCs, which include conditions such as atelectasis, pneumonia, and respiratory failure, represent significant risks for patients undergoing major surgery, often leading to prolonged hospital stays and increased healthcare costs. MZ-01 is designed for localized delivery to the respiratory system via inhalation to mitigate these risks. As of 2024, the candidate is undergoing Phase I clinical evaluation in healthy Chinese adults to assess its safety, tolerability, and pharmacokinetic profile following single and multiple ascending doses.

02

Targets

VHL (Von Hippel–Lindau tumor suppressor protein)BRD4 (Bromodomain-containing protein 4)BRD3 (Bromodomain-containing protein 3)BRD2 (Bromodomain-containing protein 2)

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