MZ-J-7-118

MZ-J-7-118 is a **synthetic peptide antagonist** of the growth hormone-releasing hormone (**GHRH**) receptor. It functions by blocking GHRH activity at its receptor, thereby inhibiting downstream signaling implicated in tumor cell proliferation. Preclinical studies show that MZ-J-7-118 **significantly inhibits the growth of human endometrial cancer cells (HEC-1A) both in vitro and in vivo**, decreasing tumor volume and weight, and prolonging tumor doubling time, without major toxic side effects. Its antitumor mechanism is primarily mediated via antagonism of GHRH receptors expressed on tumor cells, as supported by high affinity ligand binding assays. Additional effects include alterations in insulin-like growth factor I (IGF-I) levels, though suppression of serum IGF-I does not appear to be the dominant antiproliferative mechanism. MZ-J-7-118 may have broader antitumor applications due to its ability to inhibit GHRH signaling in various cancer models[1][5][3].

Other names

MZ-J-7-118MZ-J7-118MZ-J 7-118