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N-(2,6-difluorobenzyl)-4-sulfamoylbenzamide

Development stage
Preclinical
Modality
Small Molecules
01

Overview

N-(2,6-difluorobenzyl)-4-sulfamoylbenzamide is a small molecule sulfonamide derivative featuring a benzamide moiety linked to a difluorobenzyl group. It is primarily studied as an inhibitor of carbonic anhydrase II (CA II), an enzyme involved in the reversible hydration of carbon dioxide. Sulfonamides like this compound are known for their antibacterial properties and have been explored for various therapeutic applications due to their ability to inhibit enzymes such as dihydropteroate synthase and carbonic anhydrases. The presence of fluorine atoms enhances its lipophilicity and metabolic stability[5][8]. This compound has been used mainly as a research tool or discovery agent rather than as an approved pharmaceutical product[3].

Other names
N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-BenzamideN-(2,6-difluorobenzyl)-4-sulfamoylbenzamide
02

Targets

CA2 (Carbonic Anhydrase 2)

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