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N-(4-MORPHOLINE)CARBONYL-B-(1-NAPHTHYL)-L-ALANINE-L-LEUCINE BORONIC ACID
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
N-(4-MORPHOLINE)CARBONYL-B-(1-NAPHTHYL)-L-ALANINE-L-LEUCINE BORONIC ACID (DrugBank ID: DB04732) is an experimental small molecule boronic acid derivative that acts as a proteasome inhibitor. It specifically targets the beta subunits of the 20S proteasome, a large protease complex responsible for the degradation of intracellular proteins via the ubiquitin-proteasome pathway. By inhibiting the proteasome, the compound disrupts protein homeostasis, which can lead to cell cycle arrest and apoptosis, particularly in cancer cells. While structurally related to clinical proteasome inhibitors like bortezomib, this compound is primarily utilized as a research tool in biochemical and structural studies and has not advanced to clinical development for therapeutic use.
- Other names
- DB04732DB-04732DB 04732N-(4-morpholine)carbonyl-beta-(1-naphthyl)-L-alanine-L-leucine boronic acidN-(morpholinocarbonyl)-beta-(1-naphthyl)-L-alanyl-L-leucine boronic acid
02
Targets
PSMB6 (Proteasome 20S subunit beta 6)PSMB5 (Proteasome subunit beta Type-5)
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